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LRRK2 Recombinant Rabbit mAb (S-2484-164)

Leucine-rich repeat serine/threonine-protein kinase 2,Dardarin,PARK8

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6585
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    LRRK2

  • 分子别名

    Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; PARK8

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Lysosome, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion outer membrane

  • Accession

    Q5S007

  • 克隆号

    S-2484-164

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt

  • 阳性样本

    A549, SH-SY5Y, U-87MG, A172, MEF, NIH/3T3, mouse brain, rat brain

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Ms, Rt
背景介绍

  • LRRK2 (leucine-rich repeat kinase 2) is a large, multidomain protein belonging to the ROCO family, featuring a Ras-of-complex (ROC) GTPase domain followed by a C-terminal-of-ROC (COR) domain and a serine/threonine kinase domain, along with armadillo, ankyrin, leucine-rich repeat and WD40 repeat regions that collectively mediate protein–protein interactions, membrane association and autoregulation, and whose pathogenic mutations—most notably G2019S in the kinase domain—are the commonest known genetic cause of both familial and sporadic Parkinson’s disease by promoting hyper-kinase activity, mitochondrial fragmentation, autophagic-lysosomal dysfunction and neuronal toxicity.

  • 免疫印迹

    • WB result of LRRK2 Recombinant Rabbit mAb
      Primary antibody: LRRK2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: A549 whole cell lysate 20 µg
      Lane 2: SH-SY5Y whole cell lysate 20 µg
      Lane 3: U-87MG whole cell lysate 20 µg
      Lane 4: A172 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 286 kDa
      Observed MW: 270 kDa

    • WB result of LRRK2 Recombinant Rabbit mAb
      Primary antibody: LRRK2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: MEF whole cell lysate 20 µg
      Lane 2: NIH/3T3 whole cell lysate 20 µg
      Lane 3: mouse brain lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 286 kDa
      Observed MW: 270 kDa

    • WB result of LRRK2 Recombinant Rabbit mAb
      Primary antibody: LRRK2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: rat brain lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 286 kDa
      Observed MW: 270 kDa

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