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GBA Recombinant Rabbit mAb (S-3211-14)

Lysosomal acid glucosylceramidase,Lysosomal acid GCase,Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase (Beta-GC),Beta-glucosylceramidase 1,Cholesterol glucosyltransferase (SGTase),GC,GLUC,GBA1

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6581
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    GBA

  • 分子别名

    Lysosomal acid glucosylceramidase; Lysosomal acid GCase; Acid beta-glucosidase; Alglucerase; Beta-glucocerebrosidase (Beta-GC); Beta-glucosylceramidase 1; Cholesterol glucosyltransferase (SGTase); GC; GLUC; GBA1

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Lysosome

  • Accession

    P04062

  • 克隆号

    S-3211-14

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Mk

  • 阳性样本

    SH-SY5Y, U-87 MG, MCF7, 293T

  • 预测反应种属
    (反应种属缩写表)

    Pg, Cz, Or

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    IHC-P ?

    ICC ?

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Mk
    IHC-P 1:1000 Hu
背景介绍

  • GBA protein, encoded by the GBA gene on chromosome 1q21, is a 497-amino-acid lysosomal glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to glucose and ceramide; homozygous mutations cause Gaucher disease, while heterozygous mutations are the strongest common genetic risk factor for Parkinson’s disease and dementia with Lewy bodies through gain-of-function mechanisms that promote α-synuclein aggregation, impaired autophagy-lysosomal flux, and neuroinflammation, and its enzymatic activity can be enhanced by small-molecule chaperones or gene therapy, making it a key therapeutic target for both systemic and neurodegenerative disorders.

  • 免疫印迹

    • WB result of GBA Recombinant Rabbit mAb
      Primary antibody: GBA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: SH-SY5Y whole cell lysate 20 µg
      Lane 2: U-87 MG whole cell lysate 20 µg
      Lane 3: MCF7 whole cell lysate 20 µg
      Lane 4: 293T whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 60 kDa
      Observed MW: 60 kDa

    • WB result of GBA Recombinant Rabbit mAb
      Primary antibody: GBA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: COS-7 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 60 kDa
      Observed MW: 60 kDa

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human colon. Anti-GBA antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-GBA antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human lung adenocarcinoma. Anti-GBA antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of GBA in tumor tissue.

    • Expression of GBA in human tissue.

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