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Rabbit抗原名称
TYK2分子别名
Non-receptor tyrosine-protein kinase TYK2免疫原
Recombinant Protein细胞定位
Cytoplasm, Cytoskeleton, NucleusAccession
P29597克隆号
S-2740-165抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu, Ms, Rt阳性样本
MCF7, Jurkat, HeLa, U-87 MG, SH-SY5Y, Neuro-2a, mouse lung, C6, rat lung预测反应种属
(反应种属缩写表)Cz纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
WB
稀释度
应用 稀释度 推荐种属 WB 1:2000-4000 Hu, Ms, Rt IHC-P 1:100 Hu, Ms, Rt
Tyrosine kinase 2 (TYK2) is a 1,187-residue Janus kinase that, by partnering with JAK1 to phosphorylate STAT1/2/3/4/5, transduces cytokine signals from IL-12, IL-23, type I IFNs and related receptors, thereby steering Th1/Th17 differentiation, antiviral and antitumor immunity; its unique pseudokinase–kinase domain architecture allows allosteric auto-inhibition, and human missense variants that weaken this brake—such as I684S, P1104A or the catalytic V362F—confer either protection against autoimmune diseases (by dampening IL-23-driven inflammation) or, conversely, risk of systemic lupus, psoriasis, multiple sclerosis and cancers, making selective TYK2 inhibitors like deucravacitinib promising therapies.
免疫印迹
WB result of TYK2 Recombinant Rabbit mAb
Primary antibody: TYK2 Recombinant Rabbit mAb at 1/4000 dilution
Lane 1: MCF7 whole cell lysate 20 µg
Lane 2: Jurkat whole cell lysate 20 µg
Lane 3: HeLa whole cell lysate 20 µg
Lane 4: U-87 MG whole cell lysate 20 µg
Lane 5: SH-SY5Y whole cell lysate 20 µg
Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 134 kDa
Observed MW: 130 kDaWB result of TYK2 Recombinant Rabbit mAb
Primary antibody: TYK2 Recombinant Rabbit mAb at 1/4000 dilution
Lane 1: Neuro-2a whole cell lysate 20 µg
Lane 2: mouse lung lysate 20 µg
Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 134 kDa
Observed MW: 130 kDaWB result of TYK2 Recombinant Rabbit mAb
Primary antibody: TYK2 Recombinant Rabbit mAb at 1/4000 dilution
Lane 1: C6 whole cell lysate 20 µg
Lane 2: rat lung lysate 20 µg
Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 134 kDa
Observed MW: 130 kDa
免疫组化
IHC shows positive staining in paraffin-embedded human brain. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human kidney. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human gastric cancer. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung cancer. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human thyroid cancer. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse liver. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat kidney. Anti-TYK2 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of TYK2 in human tissue.
Expression of TYK2 in tumor tissue.
Expression of TYK2 in mouse & rat tissue.
FAQs
我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，我们对一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定
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