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GADD34 Recombinant Rabbit mAb (S-2267-246)

Protein phosphatase 1 regulatory subunit 15A,Growth arrest and DNA damage-inducible protein GADD34,Myeloid differentiation primary response protein MyD116 homolog,PPP1R15A

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6476

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

GADD34
分子别名

Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog; PPP1R15A
免疫原

Synthetic Peptide
细胞定位

Endoplasmic reticulum, Mitochondrion
Accession

O75807
克隆号

S-2267-246
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Mk
阳性样本

HepG2, Jurkat, K562, PC-3, COS-7
纯化方式

Protein A
浓度

2 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Mk

应用	稀释度	推荐种属
WB	1:1000	Hu, Mk

背景介绍

GADD34, also known as PPP1R15A, is a stress-inducible regulatory subunit of protein phosphatase 1 (PP1) that plays a crucial role in cellular stress responses by forming a complex with PP1 to dephosphorylate eIF2α, thereby promoting translational recovery during the integrated stress response (ISR), and is involved in various cellular processes including apoptosis, cell cycle arrest, and DNA damage response, with its expression being upregulated by a variety of stress signals such as DNA damage, endoplasmic reticulum (ER) stress, and oxidative stress, and has been implicated in several pathological conditions including cancer, neurodegenerative diseases, and metabolic disorders.

免疫印迹
- WB result of GADD34 Recombinant Rabbit mAb
  Primary antibody: GADD34 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: HepG2 whole cell lysate 20 µg
  Lane 2: Jurkat whole cell lysate 20 µg
  Lane 3: K562 whole cell lysate 20 µg
  Lane 4: PC-3 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 73 kDa
  Observed MW: 120 kDa
  This blot was developed with high sensitivity substrate
- WB result of GADD34 Recombinant Rabbit mAb
  Primary antibody: GADD34 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: COS-7 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 73 kDa
  Observed MW: 120 kDa
  This blot was developed with high sensitivity substrate