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FXR Recombinant Rabbit mAb (S-2845-71)

Bile acid receptor,Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14 (RXR-interacting protein 14),BAR,HRR1,RIP14,NR1H4

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6475

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

FXR
分子别名

Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14 (RXR-interacting protein 14); BAR; HRR1; RIP14; NR1H4
免疫原

Synthetic Peptide
细胞定位

Nucleus
Accession

Q96RI1
克隆号

S-2845-71
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
阳性样本

293T, HepG2, MCF7, MDA-MB-231, A431, HeLa, A549, HCT 116
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu

应用	稀释度	推荐种属
WB	1:1000	Hu

背景介绍

The Farnesoid X receptor (FXR, NR1H4) is a ligand-activated nuclear receptor that functions as the master bile-acid sensor: after binding physiological bile acids such as chenodeoxycholic acid, FXR heterodimerizes with RXR, translocates to DNA FXR-response elements and trans-activates or represses genes that control bile-acid synthesis (CYP7A1), conjugation (BACS, BAAT), export pumps (BSEP, MRP2) and intestinal re-uptake (IBABP, ASBT), while additionally regulating lipid and glucose metabolism, hepatic lipogenesis, energy balance, inflammatory signaling, gut barrier integrity and innate immunity; FXR exists as four human isoforms (α1–α4) and is expressed mainly in liver, intestine and kidney, with synthetic agonists (e.g. GW4064, obeticholic acid) and antagonists under intense investigation for treating cholestasis, NASH, fibrosis, diabetes and intestinal inflammatory disorders.

免疫印迹
- WB result of FXR Recombinant Rabbit mAb
  Primary antibody: FXR Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: 293T whole cell lysate 20 µg
  Lane 2: HepG2 whole cell lysate 20 µg
  Lane 3: MCF7 whole cell lysate 20 µg
  Lane 4: MDA-MB-231 whole cell lysate 20 µg
  Lane 5: A431 whole cell lysate 20 µg
  Lane 6: HeLa whole cell lysate 20 µg
  Lane 7: A549 whole cell lysate 20 µg
  Lane 8: HCT 116 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 56 kDa
  Observed MW: 56 kDa