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CLEC4C Recombinant Rabbit mAb (S-3825)

C-type lectin domain family 4 member C,Blood dendritic cell antigen 2 (BDCA-2),C-type lectin superfamily member 7,Dendritic lectin,BDCA2,CLECSF11,CLECSF7,DLEC,HECL,CLEC4C

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6459

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

CD303
分子别名

C-type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C
细胞定位

Cell membrane
Accession

Q8WTT0
克隆号

S-3825
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

IHC-P ?
稀释度

应用稀释度推荐种属

IHC-P 1:2000 Hu

应用	稀释度	推荐种属
IHC-P	1:2000	Hu

背景介绍

CD303, also known as Blood Dendritic Cell Antigen 2 (BDCA-2), is a C-type lectin receptor encoded by the CLEC4C gene, selectively expressed on human plasmacytoid dendritic cells (pDCs); it couples via the ITAM‐containing FcεRIγ adaptor to trigger Syk/Ca²⁺ signaling that drives endocytosis, the secretion of large amounts of type I interferon and pro-inflammatory cytokines, and the down-regulation of the pDC interferon response, making it both a key sentinel of viral RNA/DNA and a potential therapeutic target in autoimmunity and allergy.

免疫组化
- IHC shows positive staining in paraffin-embedded human tonsil. Anti-CLEC4C antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human spleen. Anti-CLEC4C antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human lung squamous cell carcinoma. Anti-CLEC4C antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
- Expression of CLEC4C in tumor tissue.
- Expression of CLEC4C in human tissue.