LGR4 Recombinant Rabbit mAb (S-2787-39)

LGR4 (Leucine-rich repeat-containing G-protein-coupled receptor 4) is a 951-amino-acid, 7-transmembrane glycoprotein that belongs to the B subgroup of the LGR family, distinguished by an extracellular domain with 17 leucine-rich repeats; it is broadly expressed in heart, brain, liver, kidney, endocrine and reproductive organs and serves as the principal receptor for R-spondins (RSPO1-4), which potentiate Wnt/β-catenin signaling by coupling LGR4 to the E3 ligases ZNRF3/RNF43, thereby stabilizing β-catenin and driving transcriptional programs essential for eye, kidney, bone, skin, tooth, gonad, hematopoietic, digestive and metabolic development, while also modulating NF-κB, TGF-β and other pathways to protect hepatocytes, regulate myogenesis, hematopoiesis and steroidogenesis, and its germ-line loss-of-function mutations in humans cause osteoporosis, low body weight, hypoglycemia and electrolyte imbalance, and conditional deletion in mice produces severe renal hypoplasia, underscoring its systemic role as a master regulator of organogenesis and metabolic homeostasis.