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SLC10A1/NTCP1 Recombinant Rabbit mAb (S-2844-23)

Hepatic sodium/bile acid cotransporter,Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide (NTCP6 Publications),Solute carrier family 10 member 1 (SLC10A1),NTCP

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6414

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

SLC10A1/NTCP1
分子别名

Hepatic sodium/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide (NTCP6 Publications); Solute carrier family 10 member 1 (SLC10A1); NTCP
免疫原

Synthetic Peptide
细胞定位

Cell membrane
Accession

Q14973
克隆号

S-2844-23
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
阳性样本

HepG2, Caco-2, mouse kidney, mouse liver, rat kidney, rat liver
纯化方式

Protein A
浓度

2 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000-1:2000 Hu, Ms, Rt, Mk

应用	稀释度	推荐种属
WB	1:1000-1:2000	Hu, Ms, Rt, Mk

背景介绍

The SLC10A1 gene encodes the sodium/bile acid cotransporter NTCP1, a 349-amino-acid, 7-transmembrane-domain glycoprotein that is almost exclusively expressed on the basolateral membrane of hepatocytes, where it uses the inward Na⁺ gradient to mediate high-affinity uptake of conjugated bile acids and, notably, also serves as the principal entry receptor for hepatitis B and D viruses, while additional substrates including steroid sulfates, thyroid hormones, and certain drugs link NTCP1 to systemic bile acid homeostasis, lipid metabolism, and pharmacokinetics, and inherited or acquired dysregulation of the transporter produces cholestatic disorders that are increasingly targeted by small-molecule or siRNA therapeutics.

免疫印迹
- WB result of SLC10A1/NTCP1 Recombinant Rabbit mAb
  Primary antibody: SLC10A1/NTCP1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: U-2 OS whole cell lysate 20 µg
  Lane 2: HepG2 whole cell lysate 20 µg
  Lane 3: Caco-2 whole cell lysate 20 µg
  Low expression control: U-2 OS whole cell lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 38 kDa
  Observed MW: 40 kDa
- WB result of SLC10A1/NTCP1 Recombinant Rabbit mAb
  Primary antibody: SLC10A1/NTCP1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: mouse brain lysate 20 µg
  Lane 2: mouse kidney lysate 20 µg
  Lane 3: mouse liver lysate 20 µg
  Negative control: mouse brain lysate
  Low expression control: mouse kidney lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 38 kDa
  Observed MW: 40 kDa
- WB result of SLC10A1/NTCP1 Recombinant Rabbit mAb
  Primary antibody: SLC10A1/NTCP1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: rat brain lysate 20 µg
  Lane 2: rat kidney lysate 20 µg
  Lane 3: rat liver lysate 20 µg
  Negative control: rat brain lysate
  Low expression control: rat kidney lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 38 kDa
  Observed MW: 40 kDa
- WB result of SLC10A1/NTCP1 Recombinant Rabbit mAb
  Primary antibody: SLC10A1/NTCP1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: COS-7 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 38 kDa
  Observed MW: 40 kDa