N-Myc Recombinant Rabbit mAb (S-2729-50)

N-Myc is a 64-kDa basic-helix–loop–helix–leucine-zipper transcription factor encoded by MYCN on 2p24 whose amplification or enhancer hijacking defines high-risk subsets of neuroblastoma, medulloblastoma and rhabdomyosarcoma; it heterodimerizes with MAX to bind the E-box CACGTG, recruits TRRAP–TIP60 and p300/CBP to unleash transcription of ribosomal proteins, nucleotide and polyamine biosynthetic enzymes, as well as miR-17-92, thereby driving rapid G1-S transit, metabolic rewiring toward glutaminolysis and serine synthesis, and suppression of differentiation; its intrinsically disordered N-terminus is stabilized by Aurora-A–mediated cis-prolyl isomerization that blocks ubiquitination by FBXW7, while phosphorylation at Ser62 by CDK1 primes subsequent phosphorylation at Thr58 by GSK3β to trigger SCFβ-TrCP-mediated degradation, and BET-bromodomain or HDAC inhibitors can restore this degradation in tumors harboring MYCN amplification, making N-Myc a validated but still elusive therapeutic target.