Trem2 Recombinant Rabbit mAb (S-2471-34)

TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a ~40 kDa single-pass type I transmembrane glycoprotein of the immunoglobulin superfamily that is almost exclusively expressed by microglia in the brain, where together with its signaling adaptor DAP12 it forms a receptor complex that upon binding anionic lipids, apolipoprotein E, or aggregated β-amyloid initiates phosphorylation cascades that regulate microglial survival, proliferation, metabolic reprogramming toward glycolysis and oxidative phosphorylation, and phagocytosis of apoptotic neurons and extracellular plaques, thereby maintaining central nervous system homeostasis; genetic loss-of-function variants strongly increase the risk of Alzheimer’s disease, and its ectodomain is proteolytically cleaved by ADAM10 and ADAM17 to release a soluble fragment (sTREM2) that is elevated in cerebrospinal fluid in early AD and can itself act as an immunomodulatory ligand amplifying microglial responses to pathology.