p73 alpha + beta Recombinant Rabbit mAb (S-2565-27)

The p73 alpha + beta proteins collectively denote the two major N-terminal transactivation-domain isoforms encoded by the human TP73 gene: the full-length TAp73α (containing an N-terminal TA domain, DNA-binding domain, oligomerization domain, and a long C-terminal sterile α-motif, SAM domain) and its shorter splice variant TAp73β, which retains the TA, DBD and OD but lacks the C-terminal SAM extension; both act as p53-like tumor suppressors, binding canonical p53-response elements to activate transcription of pro-apoptotic and cell-cycle arrest genes, yet they also exhibit isoform-specific roles in neuronal development, DNA damage response, chemosensitivity, and metabolic regulation, with α being more abundant in post-mitotic neurons and β predominating in proliferating epithelia, while their expression is tightly controlled through alternative promoter usage and extensive C-terminal splicing that yields additional dominant-negative ΔNp73 isoforms that antagonize the α/β tumor-suppressive activities under stress conditions.