ADAMTS5 Recombinant Rabbit mAb (S-2315-138)

ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5), encoded on chromosome 21q21.3, is a zinc-dependent secreted metalloproteinase composed of an N-terminal propeptide, a metalloproteinase catalytic domain, a disintegrin-like module, a cysteine-rich region, a spacer and two C-terminal thrombospondin type-1 repeats; it functions as the principal aggrecanase that cleaves the cartilage proteoglycans aggrecan, versican, brevican and neurocan at Glu-Xaa motifs, thereby driving extracellular-matrix turnover during development, skeletal morphogenesis, adipose-tissue remodeling and T-lymphocyte trafficking, while its dysregulated activity contributes to osteoarthritis and inflammatory joint destruction, yet, intriguingly, the same protein—via its thrombospondin repeat 1—exerts anti-angiogenic and anti-tumorigenic effects independently of catalysis by suppressing VEGF, PlGF and PD-ECGF in the tumor milieu.