Human Serum Albumin Recombinant mAb (S-2818)

Human Serum Albumin (HSA) is the most abundant plasma protein, constituting roughly half of all serum proteins. Synthesized in the liver, this 66 kDa single-chain, non-glycosylated protein serves as the circulatory system’s primary colloid, maintaining oncotic pressure and keeping fluids within blood vessels. Beyond its structural role, HSA acts as a versatile transport carrier, reversibly binding and ferrying hormones, fatty acids, bilirubin, metal ions, and numerous pharmaceuticals—thereby influencing drug pharmacokinetics and efficacy. With 17 disulfide bridges and a free cysteine at position 34, it also functions as the body’s principal extracellular antioxidant, scavenging reactive oxygen and nitrogen species. Clinically, HSA solutions are life-saving therapeutics used to restore blood volume in shock, burns, and major surgery, while recombinant and engineered HAs are emerging as targeted drug-delivery platforms and vaccines.