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ADAM8 Recombinant Rabbit mAb (S-2546-23)

Disintegrin and metalloproteinase domain-containing protein 8,Cell surface antigen MS2,CD156a,MS2

价格 600.00 供应商现货 : 3-5个工作日
货号 S0B6301
规格
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产品介绍 FAQs 评论(0)

产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    ADAM8
  • 分子别名

    Disintegrin and metalloproteinase domain-containing protein 8; Cell surface antigen MS2; CD156a; MS2
  • 免疫原

    Recombinant Protein
  • 细胞定位

    Membrane
  • Accession

    P78325
  • 克隆号

    S-2546-23
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 反应种属 ?

    Hu
  • 阳性样本

    MDA-MB-231, Capan-1, BxPC-3
  • 纯化方式

    Protein G
  • 浓度

    0.5 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu
背景介绍
  • ADAM8 (a disintegrin and metalloproteinase domain 8), also designated CD156a, is a type-I transmembrane metalloproteinase encoded at 10q26.3 that belongs to the ADAM family of cell-surface sheddases; its modular architecture comprises a pro-domain, catalytic metalloprotease, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic tail domains, endowing it with the dual capacity to cleave extracellular-matrix proteins such as fibronectin and collagen while simultaneously regulating cell–cell and cell–matrix interactions through its disintegrin motif. Physiologically, ADAM8 is expressed at highest levels in immune and neuronal tissues, where it modulates leukocyte transmigration, cytokine and chemokine shedding (e.g., TNF-α, CX3CL1), and neuronal adhesion during development and repair; pathologically, its marked up-regulation in cancers promotes epithelial-to-mesenchymal transition, angiogenesis, and metastasis by attenuating intercellular adhesion and degrading matrix barriers, and in allergic asthma it orchestrates airway remodeling and hyper-responsiveness, rendering ADAM8 a prognostic biomarker and an attractive therapeutic target for anti-metastatic and anti-inflammatory interventions .

  • 免疫印迹

    • WB result of ADAM8 Recombinant Rabbit mAb
      Primary antibody: ADAM8 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: PANC-1 whole cell lysate 20 µg
      Lane 2: MDA-MB-231 whole cell lysate 20 µg
      Lane 3: Capan-1 whole cell lysate 20 µg
      Lane 4: BxPC-3 whole cell lysate 20 µg
      Negative control: PANC-1 whole cell lysate
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 89 kDa
      Observed MW: 80-120 kDa

FAQs

斯达特公司的抗体,可以回收利用几次?

我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变,不同客户在回收抗体的保存条件上也会有差异,所以抗体回收使用效果无法保证。另外,我们对一批抗体回收验证测试,测试结果显示不同抗体可回收次数不同,一般效价越高的抗体,可重复使用的次数越多,客户可根据实验情况来确定

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