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NUP98 Recombinant Rat mAb (S-3384)

Nuclear pore complex protein Nup98-Nup96,98 kDa nucleoporin,Nucleoporin Nup98 (Nup98),Nuclear pore complex protein Nup96 Alternative names: 96 kDa nucleoporin,Nucleoporin Nup96 (Nup96),ADAR2

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6267

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rat
抗原名称

NUP98
分子别名

Nuclear pore complex protein Nup98-Nup96; 98 kDa nucleoporin; Nucleoporin Nup98 (Nup98); Nuclear pore complex protein Nup96 Alternative names: 96 kDa nucleoporin; Nucleoporin Nup96 (Nup96); ADAR2
细胞定位

Nucleus
Accession

P52948
克隆号

S-3384
抗体类型

Rat mAb
抗体同种型

IgG2c
反应种属 ?

Hu, Ms, Rt
阳性样本

HeLa, Jurkat, SH-SY5Y, NIH/3T3, RAW264.7, PC-12, C6, COS-7
纯化方式

Protein G
浓度

2 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms, Rt, Mk

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms, Rt, Mk

背景介绍

NUP98 (nucleoporin 98) is a 98-kDa component of the nuclear pore complex (NPC) generated by autoproteolytic cleavage of a 186-kDa precursor that also yields NUP96 . Anchored on the nucleoplasmic face of the NPC, it contains N-terminal GLFG/FG repeats that serve as docking sites for transport receptors during nucleocytoplasmic trafficking of proteins and RNAs, while its C-terminal RNA-binding domain participates in mRNA export and gene-expression regulation . Beyond transport, NUP98 dynamically associates with mitotic structures to control spindle assembly and mitotic progression, forms liquid-droplet compartments that sequester damaged DNA to safeguard genome integrity, and acts as a transcriptional coactivator or corepressor by localizing to developmental gene loci. Chromosomal translocations that fuse the N-terminal portion of NUP98 to over 30 partner proteins (e.g., homeodomain transcription factors) generate potent oncoproteins that drive aggressive forms of acute myeloid leukemia and T-cell acute lymphoblastic leukemia, highlighting its pivotal role in both normal cellular physiology and oncogenesis.

免疫印迹
- WB result of NUP98 Recombinant Rat mAb
  Primary antibody: NUP98 Recombinant Rat mAbat 1/1000 dilution
  Lane 1: HeLa nuclear lysate 20 µg
  Lane 2: HeLa whole cell lysate 20 µg
  Lane 3: Jurkat whole cell lysate 20 µg
  Lane 4: SH-SY5Y whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 98 kDa
  Observed MW: 98 kDa
- WB result of NUP98 Recombinant Rat mAb
  Primary antibody: NUP98 Recombinant Rat mAbat 1/1000 dilution
  Lane 1: NIH/3T3 whole cell lysate 20 µg
  Lane 2: RAW264.7 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 98 kDa
  Observed MW: 98 kDa
- WB result of NUP98 Recombinant Rat mAb
  Primary antibody: NUP98 Recombinant Rat mAbat 1/1000 dilution
  Lane 1: PC-12 whole cell lysate 20 µg
  Lane 2: C6 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 98 kDa
  Observed MW: 98 kDa
- WB result of NUP98 Recombinant Rat mAb
  Primary antibody: NUP98 Recombinant Rat mAbat 1/1000 dilution
  Lane 1: COS-7 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 98 kDa
  Observed MW: 98 kDa