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Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb (S-1553-9)

Mitogen-activated protein kinase 14,MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein (CSAID-binding protein,CSBP),MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha (MAP kinase p38 alpha),Stress-activated protein kinase 2a (SAPK2a),CSBP,CSBP1,CSBP2,CSPB1,MXI2,SAPK2A,MAPK14

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6266

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

Phospho-p38 MAPK (Thr180)
分子别名

Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein (CSAID-binding protein; CSBP); MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha (MAP kinase p38 alpha); Stress-activated protein kinase 2a (SAPK2a); CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAPK14
免疫原

Synthetic Peptide
细胞定位

Cytoplasm, Nucleus
Accession

Q16539
克隆号

S-1553-9
抗体类型

Recombinant mAb
抗体同种型

IgG
翻译后修饰类型

磷酸化
反应种属 ?

Hu, Ms, Rt
预测反应种属
(反应种属缩写表)

Dg, Cp, Cz, Zf
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

Dot Blot 1:1000
WB 1:1000 Hu, Ms, Rt

应用	稀释度	推荐种属
Dot Blot	1:1000
WB	1:1000	Hu, Ms, Rt

背景介绍

Phospho-p38 MAPK (Thr180) is the dual-phosphorylated, enzymatically active form of the p38 mitogen-activated protein kinase in which the conserved threonine residue at position 180 (within the canonical Thr-X-Tyr activation motif, TGY in human p38α) is phosphorylated, together with Tyr182, by upstream MAP kinase kinases (MKK3/6 or MKK4), resulting in a conformational switch that opens the ATP- and substrate-binding sites, thereby enabling the kinase to transduce stress, inflammatory, and cytokine signals to downstream transcription factors (e.g., ATF-2, CHOP, MEF2C) and other effectors, ultimately governing cellular responses such as apoptosis, differentiation, and cytokine production.

免疫印迹
- WB result of Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb
  Primary antibody: Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: untreated HeLa whole cell lysate 20 µg
  Lane 2: HeLa treated with 25 μM Anisomycin for 30 minutes whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 41 kDa
  Observed MW: 38 kDa
- WB result of Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb
  Primary antibody: Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: untreated C6 whole cell lysate 20 µg
  Lane 2: C6 treated with 25 μg/ml Anisomycin for 30 minutes whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 41 kDa
  Observed MW: 38 kDa
斑点杂交
- Dot blot result of Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb
  Lane 1: p38 MAPK (Thr180) phospho peptide 1
  Lane 2: p38 MAPK (Thr180) phospho peptide 2
  Lane 3: p38 MAPK (Thr182) phospho peptide
  Lane 4: p38 MAPK unmodified peptide
  Primary antibody: Phospho-p38 MAPK (Thr180) Recombinant Rabbit mAb at 1/1000 dilution
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution