Acetyl-CoA Carboxylase Rabbit Polyclonal Antibody

Acetyl-CoA Carboxylase (ACC) is a crucial metabolic enzyme that plays a central role in fatty acid metabolism. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC exists in two isoforms: ACC1 (ACACA), primarily localized in the cytosol and regulating fatty acid synthesis, and ACC2 (ACACB), which is associated with the outer mitochondrial membrane. The malonyl-CoA produced by ACC2 inhibits carnitine palmitoyltransferase-1 (CPT-1), thereby regulating fatty acid β-oxidation. The enzyme is tightly controlled by multiple mechanisms, including allosteric regulation (activation by citrate, inhibition by long-chain acyl-CoA), reversible phosphorylation (inactivation by AMPK and PKA), and transcriptional regulation (e.g., SREBP-1c-mediated expression upregulation). Due to its pivotal role in energy metabolism, ACC is a potential therapeutic target for obesity, diabetes, and cancer, with inhibitors (e.g., TOFA, ND-630) currently under investigation. Additionally, plant and bacterial ACCs are targets for herbicides (e.g., aryloxyphenoxypropionates) and antibiotics, highlighting their broad biological significance.