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BCRP/ABCG2 Recombinant Rabbit mAb (S-2365-67)

Broad substrate specificity ATP-binding cassette transporter ABCG2,ATP-binding cassette sub-family G member 2,Breast cancer resistance protein,CDw338,Mitoxantrone resistance-associated protein,Placenta-specific ATP-binding cassette transporter,Urate exporter,CD338,ABCP,BCRP1,MXR

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6258

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

BCRP/ABCG2
分子别名

Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD338; ABCP; BCRP1; MXR
免疫原

Recombinant Protein
细胞定位

Mitochondrion, Cell membrane
Accession

Q9UNQ0
克隆号

S-2365-67
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
阳性样本

A549, PANC-1, mouse liver, rat liver
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000-1:2000 Hu, Ms, Rt

应用	稀释度	推荐种属
WB	1:1000-1:2000	Hu, Ms, Rt

背景介绍

The breast cancer resistance protein (BCRP/ABCG2), encoded by the ABCG2 gene, is a 655-amino-acid, 72–75 kDa half-transporter (a member of the ABC transporter superfamily G subfamily) that forms homodimers or oligomers to function as an ATP-dependent efflux pump actively transporting a broad range of substrates—including anticancer drugs (e.g., mitoxantrone, topotecan), endogenous compounds (e.g., estrone-3-sulfate, uric acid), and xenobiotics—across apical membranes of tissues such as the placenta, intestine, liver, kidney proximal tubules, and brain microvascular endothelium, thereby contributing to drug absorption, distribution, and elimination, protecting against xenobiotic exposure, and conferring multidrug resistance in cancer, particularly acute myeloid leukemia.

免疫印迹
- WB result of BCRP/ABCG2 Recombinant Rabbit mAb
  Primary antibody: BCRP/ABCG2 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: unboiled A204 whole cell lysate 20 µg
  Lane 2: unboiled A549 whole cell lysate 20 µg
  Lane 3: unboiled PANC-1 whole cell lysate 20 µg
  Negative control: unboiled A204 whole cell lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 72 kDa
  Observed MW: 80 kDa
- WB result of BCRP/ABCG2 Recombinant Rabbit mAb
  Primary antibody: BCRP/ABCG2 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: unboiled mouse liver lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 72 kDa
  Observed MW: 80 kDa
- WB result of BCRP/ABCG2 Recombinant Rabbit mAb
  Primary antibody: BCRP/ABCG2 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: unboiled rat liver lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 72 kDa
  Observed MW: 80 kDa