CDC7 Recombinant Rabbit mAb (S-2159-50)

CDC7 (cell division cycle 7-related protein kinase) is a highly conserved, nuclear serine/threonine kinase encoded by the CDC7 gene that governs the initiation of DNA replication at the G1/S transition by forming an active complex with its regulatory subunit Dbf4 (ASK in mammals); this CDC7-Dbf4/ASK complex phosphorylates the MCM2–7 helicase components of the pre-replication complex, thereby triggering origin firing and S-phase entry, while its activity is kept constant throughout the cell cycle by post-translational control rather than changes in CDC7 levels. Loss or inhibition of CDC7 arrests DNA synthesis and can lead to p53-mediated apoptosis, whereas its overexpression—frequently observed in colorectal, lung, breast and hematological malignancies—correlates with neoplastic transformation and may be exploited therapeutically with CDC7 inhibitors.