PTK2B Recombinant Rabbit mAb (S-2417-80)

PTK2B (also known as PYK2, FAK2, or RAFTK) is a cytoplasmic protein tyrosine kinase encoded by the PTK2B gene on 8p21.2 that belongs to the focal adhesion kinase (FAK) subfamily; it functions as a calcium-sensitive signaling hub, undergoing rapid tyrosine phosphorylation and activation in response to elevated intracellular Ca²⁺, nicotinic acetylcholine receptor stimulation, membrane depolarization or PKC activation, and it transduces these stimuli into downstream MAPK cascades and neuronal activity modulation by physically coupling neuropeptide or neurotransmitter receptors to CRK-associated substrate, nephrocystin, the FAK-associated GTPase regulator, GRB2-SH2, and numerous other partners including BCAR1, Cbl, paxillin and Src. More recently PTK2B has been shown to promote antiviral innate immunity by interacting with and phosphorylating TBK1 at Tyr591 to enhance TBK1 oligomerization, while also augmenting STING oligomerization through a kinase-independent mechanism, thereby potentiating STING-TBK1 signaling.