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Phospho-STING (Ser366) Recombinant Rabbit mAb (S-2243-62)

Stimulator of interferon genes protein,hSTING,Endoplasmic reticulum interferon stimulator (ERIS),Mediator of IRF3 activation (hMITA),Transmembrane protein 173,ERIS,MITA s,STING s,TMEM173,STING1

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6157
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产品介绍

产品介绍 FAQs 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Phospho-STING (Ser366)

  • 分子别名

    Stimulator of interferon genes protein; hSTING; Endoplasmic reticulum interferon stimulator (ERIS); Mediator of IRF3 activation (hMITA); Transmembrane protein 173; ERIS; MITA s; STING s; TMEM173; STING1

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Endoplasmic reticulum, Cytoplasm, Lysosome, Mitochondrion, Cell membrane

  • Accession

    Q86WV6

  • 克隆号

    S-2243-62

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 翻译后修饰类型

    磷酸化

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    Dot Blot 1:1000
    WB 1:1000-1:2000 Hu
背景介绍

  • Phospho-STING (Ser366) protein is a phosphorylated form of the stimulator of interferon genes (STING) protein, specifically phosphorylated at serine 366. STING is a key component of the innate immune system, playing a crucial role in the cytosolic DNA sensing pathway. When phosphorylated at Ser366, STING is activated and promotes the production of type I interferons and other pro-inflammatory cytokines in response to pathogen-associated molecular patterns or DNA damage. This phosphorylation event is essential for the downstream signaling cascade that leads to the activation of immune cells and the initiation of an antiviral or antibacterial response. Abnormal regulation of Phospho-STING (Ser366) has been implicated in various immune-related diseases, making it a potential target for therapeutic interventions.

  • 免疫印迹

    • WB result of Phospho-STING (Ser366) Recombinant Rabbit mAb
      Primary antibody: Phospho-STING (Ser366) Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: untreated THP-1 whole cell lysate 20 µg
      Lane 2: THP-1 differentiated with 80 nM TPA for 16 hours, then treated with 100nM Calyculin A for 30 minutes whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 42 kDa
      Observed MW: 38 kDa
      This blot was developed with high sensitivity substrate

  • 斑点杂交

    • Dot blot result of Phospho-STING (Ser366) Recombinant Rabbit mAb
      Lane 1: STING (Ser366) phospho peptide
      Lane 2: STING (Ser366) unmodified peptide
      Primary antibody: Phospho-STING (Ser366) Recombinant Rabbit mAb at 1/1000 dilution
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution

FAQs

斯达特公司的抗体，可以回收利用几次？

我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，我们对一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定

检测磷酸化蛋白时，推荐有什么封闭体系？

我们推荐客户使用TPST+5%脱脂奶粉来稀释一抗，进行封闭。 虽然BSA被推荐为WB检测磷酸化蛋白的常用封闭剂，但是脱脂奶粉获取更加方便，覆盖更广泛的非特异性结合位点，在一抗性能优越的前提下，使用脱脂奶粉封闭性价比更高

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