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Merlin Recombinant Rabbit mAb (S-2331-22)

Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin,SCH,NF2

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6131
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产品介绍

产品介绍 FAQs 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Merlin

  • 分子别名

    Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; SCH; NF2

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Nucleus, Cell projection

  • Accession

    P35240

  • 克隆号

    S-2331-22

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt

  • 阳性样本

    HeLa, PC-3, MCF7, HepG2, MEF, mouse brain, rat brain

  • 预测反应种属
    (反应种属缩写表)

    Bb

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000-1:2000 Hu, Ms, Rt, AfGrMk
背景介绍

  • Merlin protein, also known as neurofibromin 2 (NF2), is a crucial tumor suppressor protein encoded by the NF2 gene. It plays a vital role in regulating cell proliferation, differentiation, and apoptosis. Merlin acts as a negative regulator of the Hippo signaling pathway, which is essential for controlling organ size and cell fate determination. When functioning normally, Merlin helps to inhibit the overgrowth of cells and prevents the formation of tumors. Mutations in the NF2 gene that lead to a loss of functional Merlin protein are associated with the development of various types of cancer, including schwannomas, meningiomas, and mesotheliomas. In addition to its role in cancer, Merlin is also involved in the regulation of cell adhesion and the maintenance of cellular architecture. Ongoing research is focused on understanding the detailed mechanisms of Merlin's action and exploring potential therapeutic strategies targeting the Merlin-Hippo pathway for cancer treatment.

  • 免疫印迹

    • WB result of Merlin Recombinant Rabbit mAb
      Primary antibody: Merlin Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: HeLa whole cell lysate 20 µg
      Lane 2: PC-3 whole cell lysate 20 µg
      Lane 3: MCF7 whole cell lysate 20 µg
      Lane 4: HepG2 whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 70 kDa
      Observed MW: 70 kDa

    • WB result of Merlin Recombinant Rabbit mAb
      Primary antibody: Merlin Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: MEF whole cell lysate 20 µg
      Lane 2: mouse brain lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 70 kDa
      Observed MW: 70 kDa

    • WB result of Merlin Recombinant Rabbit mAb
      Primary antibody: Merlin Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: rat brain lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 70 kDa
      Observed MW: 70 kDa

    • WB result of Merlin Recombinant Rabbit mAb
      Primary antibody: Merlin Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: COS-7 whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 70 kDa
      Observed MW: 70 kDa

FAQs

斯达特公司的抗体，可以回收利用几次？

我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，我们对一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定

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