Rig-I Recombinant Rabbit mAb (S-2293-22)

RIG-I（Retinoic acid-inducible gene I）is a key protein in the innate immune system that plays a crucial role in detecting viral infections. It is an intracellular pattern recognition receptor that primarily recognizes double-stranded RNA and 5′-triphosphate single-stranded RNA, which are often produced during viral replication. When RIG-I binds to these viral RNA molecules, it undergoes conformational changes and activates downstream signaling pathways, including the induction of type I interferons such as IFN-α and IFN-β. These interferons help to establish an antiviral state in infected and neighboring cells by upregulating the expression of various antiviral proteins. RIG-I is highly expressed in immune cells like dendritic cells and macrophages, as well as in many other cell types. Its function is essential for the early detection and response to RNA viruses, making it a vital component of the host's defense mechanism against viral infections.