CD88 Recombinant Rabbit mAb (S-1921-43)

C5a anaphylatoxin chemotactic receptor 1,C5a anaphylatoxin chemotactic receptor (C5a-R,C5aR),C5AR,C5R1,C5AR1

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6086

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

CD88
分子别名

C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR); C5AR; C5R1; C5AR1
免疫原

Synthetic Peptide
细胞定位

Cell membrane
Accession

P21730
克隆号

S-1921-43
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
阳性样本

Human peripheral blood cells
预测反应种属
(反应种属缩写表)

Cz
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

IHC-P ?

FCM
稀释度

应用稀释度推荐种属

IHC-P 1:1000 Hu
FCM 1:500 Hu

应用	稀释度	推荐种属
IHC-P	1:1000	Hu
FCM	1:500	Hu

背景介绍

CD88, also known as C5a receptor 1 (C5aR1), is a G protein-coupled receptor that plays a crucial role in the immune system. It is primarily expressed on various immune cells, including neutrophils, monocytes, macrophages, and some endothelial cells. The binding of the anaphylatoxin C5a to CD88 triggers a wide range of biological responses, such as chemotaxis, degranulation, and the release of pro-inflammatory cytokines, which are essential for the recruitment of immune cells to sites of infection or inflammation. Additionally, CD88-mediated signaling can enhance phagocytosis and promote the activation of the immune response. Dysregulation of CD88 function has been implicated in several inflammatory and autoimmune diseases, making it a potential therapeutic target for interventions aimed at modulating immune responses.

流式分析
- Flow cytometric analysis of Human peripheral blood cells labelling CD88 antibody at 1/500 (0.1 μg) dilution/ (Right panel) compared with a Rabbit IgG Isotype Control / (Left panel). Goat Anti-Rabbit IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD11b - Brilliant Violet 421™ antibody separately.
免疫组化
- IHC shows positive staining in paraffin-embedded human spleen. Anti-CD88 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human colon cancer. Anti-CD88 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
- Expression of CD88 in tumor tissue.
- Expression of CD88 in human tissue.