PADI4/PAD4 Recombinant Rabbit mAb (S-4347-19)

Protein-arginine deiminase type-4 (PAD4) is a human enzyme encoded by the PADI4 gene, located on the short arm of chromosome 1. PAD4 is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline in proteins, a process known as citrullination. It is primarily expressed in white blood cells such as granulocytes and monocytes, and can also be found in the nucleus. PAD4 plays a crucial role in the formation of neutrophil extracellular traps (NETs), which are involved in the immune response against pathogens. However, excessive PAD4 activity and NET formation have been implicated in various diseases, including rheumatoid arthritis, multiple sclerosis, cancer, and cardiovascular diseases. PAD4 also influences gene expression by deimininating histones, and its dysregulation can impact cellular processes like apoptosis and differentiation. Due to its involvement in multiple disease pathways, PAD4 has become a promising target for therapeutic interventions.