GAD1/GAD67 Recombinant Rabbit mAb (S-4437-20)

Glutamate decarboxylase 1 (GAD1, also known as GAD67), encoded by the GAD1 gene, is a key enzyme in the central nervous system responsible for synthesizing the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Using pyridoxal phosphate as a cofactor, it catalyzes the decarboxylation of glutamate to produce GABA and carbon dioxide. This 67 kDa protein is predominantly localized in the cytoplasm and functions as a homodimer, playing a central role in maintaining the excitation-inhibition balance in the brain. Dysfunction of GAD1 is associated with various diseases—for example, it serves as an autoantigen in type 1 diabetes and stiff-person syndrome. Additionally, defects in this gene may lead to developmental and epileptic encephalopathy accompanied by seizures, or be linked to neurodevelopmental disorders such as spastic quadriplegic cerebral palsy.