ZC3H13 Recombinant Rabbit mAb (S-5530)

ZC3H13, also known as zinc finger CCCH domain-containing protein 13, is a core component of the RNA N⁶-methyladenosine (m⁶A) methyltransferase complex (i.e., the WMM complex) and plays a critical role in regulating gene expression and cellular functions. Acting as an "anchoring" and "bridging" protein within this complex, ZC3H13 is responsible for stably recruiting and tethering other components of the complex (such as WTAP and RBM15) to the nucleus, thereby ensuring that the methyltransferase complex can precisely install m⁶A modifications on the 3′ untranslated regions of mRNAs. This function deeply involves it in RNA metabolic processes including mRNA splicing and processing, and is essential for maintaining the stemness and pluripotency of embryonic stem cells. Given its central role in epitranscriptional regulation, dysregulation of ZC3H13 function has been closely linked to various diseases: in multiple cancers (such as colorectal cancer, liver cancer, and pancreatic cancer), alterations in its expression levels can affect tumor cell proliferation, invasion, chemotherapy sensitivity, and prognosis, exhibiting a "double-edged sword" effect—with some studies suggesting a tumor-suppressive role while others indicate a pro-tumorigenic function. Additionally, this protein has also been associated with genetic risk for schizophrenia, keloid formation, and various viral infections, among other pathological processes.