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IGF1 Receptor Recombinant Rabbit mAb (S-1617-146)

Insulin-like growth factor 1 receptor,Insulin-like growth factor I receptor (IGF-I receptor),CD221,IGF1R

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6020
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产品介绍

产品介绍 FAQs 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    IGF1 Receptor

  • 分子别名

    Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor (IGF-I receptor); CD221; IGF1R

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Cell membrane

  • Accession

    P08069

  • 克隆号

    S-1617-146

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt

  • 阳性样本

    MCF7, A431, HepG2, HeLa, HCT 116, MDA-MB-231, HEK-293, C2C12, NIH/3T3, mouse brain, mouse spleen, C6, rat brain

  • 预测反应种属
    (反应种属缩写表)

    Bv

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Ms, Rt
背景介绍

  • The insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase that is widely expressed on the surface of human cells and plays a crucial role in cell growth, proliferation, and differentiation. It is activated by insulin-like growth factor 1 (IGF-1) and IGF-2, and to a lesser extent by insulin. The IGF-1R is structurally similar to the insulin receptor and consists of two extracellular α-subunits involved in ligand binding and two transmembrane β-subunits containing a tyrosine kinase domain. Upon activation, IGF-1R triggers several intracellular signaling pathways, including the PI3K/Akt/mTOR and RAS/RAF/MAPK pathways, which promote cell survival, inhibit apoptosis, and regulate metabolism. Additionally, IGF-1R has been found to migrate to the cell nucleus, where it can act as a transcriptional activator. Given its significant anti-apoptotic and pro-survival functions, IGF-1R is highly expressed in many types of cancer and is considered a promising target for cancer therapy.

  • 免疫印迹

    • WB result of IGF1 Receptor Recombinant Rabbit mAb
      Primary antibody: IGF1 Receptor Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: MCF7 whole cell lysate 20 µg
      Lane 2: A431 whole cell lysate 20 µg
      Lane 3: HepG2 whole cell lysate 20 µg
      Lane 4: HeLa whole cell lysate 20 µg
      Lane 5: HCT 116 whole cell lysate 20 µg
      Lane 6: MDA-MB-231 whole cell lysate 20 µg
      Lane 7: HEK-293 whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 155 kDa
      Observed MW: 100, 200 kDa

    • WB result of IGF1 Receptor Recombinant Rabbit mAb
      Primary antibody: IGF1 Receptor Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: C2C12 whole cell lysate 20 µg
      Lane 2: NIH/3T3 whole cell lysate 20 µg
      Lane 3: mouse brain lysate 20 µg
      Lane 4: mouse spleen lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 155 kDa
      Observed MW: 105, 200 kDa

    • WB result of IGF1 Receptor Recombinant Rabbit mAb
      Primary antibody: IGF1 Receptor Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: C6 whole cell lysate 20 µg
      Lane 2: rat brain lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 155 kDa
      Observed MW: 110, 200 kDa

FAQs

斯达特公司的抗体，可以回收利用几次？

我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，我们对一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定

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