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FoxM1 Recombinant Rabbit mAb (S-3223-138)

Forkhead box protein M1,Forkhead-related protein FKHL16,Hepatocyte nuclear factor 3 forkhead homolog 11 (HFH-11,HNF-3/fork-head homolog 11),M-phase phosphoprotein 2,MPM-2 reactive phosphoprotein 2,Transcription factor Trident,Winged-helix factor from INS-1 cells,FKHL16,HFH11,MPP2,WIN

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B60075
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    FOXM1

  • 分子别名

    Forkhead box protein M1; Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11 (HFH-11; HNF-3/fork-head homolog 11); M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cells; FKHL16; HFH11; MPP2; WIN

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Nucleus

  • Accession

    Q08050

  • 克隆号

    S-3223-138

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 阳性样本

    HeLa treated with 2 µM aphidicolin for 24 hours

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.02% sodium azide

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu
背景介绍

  • FOXM1 is a transcription factor of the Forkhead box family that orchestrates cell-cycle progression by directly activating genes required for G1/S and G2/M transitions, DNA replication, and mitosis; its expression is normally low in quiescent cells but rises sharply from late G1 through M phase, and it is frequently over-expressed in human cancers where it promotes proliferation, angiogenesis, metastasis, and chemo-radiotherapy resistance through pathways including PI3K/AKT, Wnt/β-catenin, and p53; post-translational modifications such as phosphorylation by CDK, PLK1 and AKT, together with ubiquitin-mediated degradation, tightly regulate FOXM1 activity, making it both a key biomarker for poor prognosis and an attractive therapeutic target in oncology.

  • 免疫印迹

    • WB result of FoxM1 Recombinant Rabbit mAb
      Primary antibody: FoxM1 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: HeLa whole cell lysate 20 µg
      Lane 2: untreated HeLa whole cell lysate 20 µg
      Lane 3: HeLa treated with 2 µM aphidicolin for 24 hours whole cell lysate 20 µg Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 84 kDa
      Observed MW: 110 kDa

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