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宿主来源
Rabbit抗原名称
ADGRE1 (F4/80)分子别名
Adhesion G protein-coupled receptor E1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; EMR1; TM7LN3免疫原
Recombinant Protein细胞定位
Cell membraneAccession
Q14246克隆号
S-2683-205抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
稀释度
应用 稀释度 推荐种属 IHC-P 1:500 Hu
ADGRE1 (Adhesion G protein-coupled receptor E1, also known as EMR1 or F4/80) is a structurally unique macrophage marker membrane protein that plays an important role in immune surveillance and inflammatory regulation. This protein is characterized by a long extracellular N-terminal region containing six epidermal growth factor (EGF)-like modules, connected via a serine/threonine-rich domain to the classic C-terminal seven-transmembrane G protein-coupled receptor domain—a conformation that endows it with dual potential for both cell adhesion and signal transduction. As the most classic macrophage surface marker F4/80 in mice, as well as a functionally conserved receptor in humans, ADGRE1 is primarily localized to the cell membrane and participates in regulating macrophage biological functions, mediating peripheral immune tolerance, and maintaining tissue homeostasis through activation of the adenylate cyclase signaling pathway. Although its specific endogenous ligands remain incompletely defined, studies have shown that this receptor is associated with various disease states, including obesity, fibrosis, and inflammatory bowel disease, highlighting its potential research value in immune-related pathological processes.
免疫组化
IHC shows positive staining in paraffin-embedded human liver. Anti-ADGRE1 (F4/80) antibody was used at 1/500 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human spleen. Anti-ADGRE1 (F4/80) antibody was used at 1/500 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human stomach. Anti-ADGRE1 (F4/80) antibody was used at 1/500 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung cancer. Anti-ADGRE1 (F4/80) antibody was used at 1/500 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human colon. Anti-ADGRE1 (F4/80) antibody was used at 1/500 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of ADGRE1 (F4/80) in tumor tissues.
Expression of ADGRE1 (F4/80) in human tissues.
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