Biotin Mouse Anti-Human CD66b Antibody (G10F5)
Cell adhesion molecule CEACAM8,CD67 antigen,Carcinoembryonic antigen CGM6,Carcinoembryonic antigen-related cell adhesion molecule 8 (CEA cell adhesion molecule 8Imported),Non-specific cross-reacting antigen NCA-95,CGM6,CEACAM8
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宿主来源
Mouse抗原名称
CD66b分子别名
Cell adhesion molecule CEACAM8; CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8 (CEA cell adhesion molecule 8Imported); Non-specific cross-reacting antigen NCA-95; CGM6; CEACAM8细胞定位
Cell membraneAccession
P31997克隆号
G10F5抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human peripheral blood Leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD66b, also known as CEACAM8, is a cell surface glycoprotein and a member of the immunoglobulin superfamily, specifically the carcinoembryonic antigen (CEA)-like subfamily. It is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 95-100 kDa. CD66b is primarily expressed on granulocytes, including neutrophils and eosinophils, and plays a significant role in cell adhesion in a calcium-independent manner. It mediates heterophilic adhesion with other CEA-related cell adhesion molecules, such as CD66c, and is particularly involved in the activation and adhesion of neutrophils. Additionally, CD66b has been implicated in various biological processes, including the regulation of eosinophil activation and the immune response in allergic diseases and parasitic infections. In cancer research, CD66b expression has been associated with prognosis in non-small cell lung cancer, with higher levels in the immune stroma linked to poorer outcomes.
流式分析
Flow cytometric analysis of Human CD66b expression on human peripheral blood Leukocytes. Human peripheral blood Leukocytes were stained with either Biotin Mouse IgG Isotype Control (Left panel) or SDT Biotin Mouse Anti-Human CD66b Antibody (Right panel) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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