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宿主来源
Mouse抗原名称
NCAM-1/CD56分子别名
Neural cell adhesion molecule 1; N-CAM-1; NCAM; NCAM1免疫原
Recombinant Protein细胞定位
Secreted, Cell membraneAccession
P13591克隆号
S-577-58抗体类型
Mouse mAb抗体同种型
IgG1,λ反应种属 ?
Hu阳性样本
Human peripheral blood lymphocytes纯化方式
Protein G浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a cell adhesion protein belonging to the immunoglobulin superfamily. It is expressed on various cell types including neurons, muscle cells, and immune cells like natural killer (NK) cells. NCAM-1/CD56 plays crucial roles in cell-to-cell and cell-matrix interactions during development and differentiation, regulating processes such as neurogenesis, neurite outgrowth, axonal guidance, and cell migration in the nervous system. In the immune system, it is involved in the expansion of T lymphocytes, B lymphocytes, and NK cells. NCAM-1/CD56 also triggers signaling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). Additionally, it serves as a biomarker for certain diseases, such as malignant tumors in the nervous system and neuroendocrine carcinoma.
流式分析
Flow cytometric analysis of Human CD56 expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either FITC Mouse IgG1, κ Isotype Control (Left panel) or FITC Mouse Anti-Human NCAM-1/CD56 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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