FITC Mouse Anti-Human CD203c Antibody (NP4D6)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 1 Publication,E-NPP 3,NPP3,Alkaline phosphodiesterase I,Dinucleoside polyphosphatase,Nucleotide diphosphatase,Nucleotide pyrophosphatase (NPPase),Phosphodiesterase I beta (PD-Ibeta),Phosphodiesterase I/nucleotide pyrophosphatase 3,PDNP3,ENPP3
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宿主来源
Mouse抗原名称
CD203c分子别名
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 1 Publication; E-NPP 3; NPP3; Alkaline phosphodiesterase I; Dinucleoside polyphosphatase; Nucleotide diphosphatase; Nucleotide pyrophosphatase (NPPase); Phosphodiesterase I beta (PD-Ibeta); Phosphodiesterase I/nucleotide pyrophosphatase 3; PDNP3; ENPP3细胞定位
Secreted, Cell membraneAccession
O14638克隆号
NP4D6抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD203c, also known as ectonucleotide pyrophosphatase/phosphodiesterase-3 (E-NPP3), is a type II transmembrane protein belonging to the ectonucleotide pyrophosphatase/phosphodiesterase family. It is specifically expressed on basophil-committed progenitor cells and mature basophils, and to a lesser extent on tissue mast cells. CD203c is rapidly upregulated on the cell surface upon basophil activation, such as through cross-linking of the IgE receptor, making it a valuable activation marker for these cells. It plays a role in regulating the inflammatory response by hydrolyzing ATP, which helps suppress chronic allergic inflammation. Additionally, CD203c has been identified as a potential biomarker for basophilia in diseases like chronic myeloid leukemia (CML), where its expression levels correlate with disease severity and treatment response.
流式分析
Flow cytometric analysis of Human CD203c expression on Human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with PE-Cy7 Mouse Anti-Human CD123 Antibody and either FITC Mouse IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD203c Antibody (Right panel) at 5 μl/test. Total viable cells, as determined by Fixable Viability Dye 452 (S0D0021), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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