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宿主来源
Rabbit抗原名称
CLEC4A分子别名
C-type lectin domain family 4 member A; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor; CD367; CLECSF6; DCIR; LLIR免疫原
Synthetic Peptide细胞定位
Cell membraneAccession
Q9UMR7克隆号
S-2104-129抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CLEC4A (C-type lectin domain family 4 member A), also known as DCIR or CD367, is a type II transmembrane inhibitory receptor expressed mainly on dendritic cells and other myeloid cells; it contains an extracellular C-type lectin-like domain that binds glycan structures independent of calcium, a single transmembrane segment, and a cytoplasmic tail harboring an immunoreceptor tyrosine-based inhibitory motif (ITIM) which, upon ligand engagement, recruits phosphatases SHP-1/2 to down-regulate TLR signaling, suppress pro-inflammatory cytokine production, and maintain immune homeostasis, while also serving as an attachment factor for pathogens such as HIV-1.
流式分析
Flow cytometric analysis of Human PBMC labelling CLEC4A antibody at 1/200 (1 μg) dilution (Right panel) compared with a Rabbit IgG Isotype Control (Left panel). Goat Anti-Rabbit IgG DyLight Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD11b - Brilliant Violet 421™ antibody separately.
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