Mouse Anti-Human CD83 Antibody (HB15e)

CD83 is a ~45 kDa, heavily glycosylated type-I transmembrane glycoprotein of the immunoglobulin superfamily that is encoded on human chromosome 6 and expressed chiefly on mature dendritic cells, Langerhans cells and activated lymphocytes, where it serves as a key maturation marker whose extracellular V-set Ig-like domain can dimerize via a membrane-proximal cysteine and whose membrane-bound form drives potent T-cell stimulation while its proteolytically released soluble counterpart (sCD83) exerts potent immunosuppressive effects by inhibiting dendritic-cell maturation and cytokine production, thereby modulating both the initiation and resolution of adaptive immune responses.