Biotin Mouse Anti-Human CD124 Antibody (S-3171)

CD124, also known as the interleukin-4 receptor alpha chain (IL-4Rα), is a member of the cytokine receptor superfamily and a key component of Type II cytokine receptors. It primarily functions by forming two distinct types of receptors through pairing with different chains: Type I receptor is composed of CD124 and the common gamma chain (γc), primarily mediating IL-4 signal transduction; the Type II receptor is formed by CD124 and the interleukin-13 receptor alpha 1 chain (IL-13Rα1), which can mediate signals for both IL-4 and IL-13. CD124 plays a central role in activating the JAK-STAT signaling pathway (particularly STAT6), thereby regulating the proliferation, differentiation, and antibody class switching of B cells and T cells, as well as macrophage polarization. It is critically important in allergic responses, inflammation, anti-parasitic immunity, and the tumor microenvironment. Dysregulation of its function is closely associated with allergic diseases such as asthma and atopic dermatitis, as well as certain autoimmune disorders and cancers.