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宿主来源
Armenian hamster抗原名称
CD30分子别名
Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Lymphocyte activation antigen CD30; Tnfrsf8细胞定位
Cell membraneAccession
Q60846克隆号
mCD30.1抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms阳性样本
ConA-treated C57BL/6 mouse splenocytes.纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:400 Ms
CD30 (TNFRSF8) is a 120 kDa type-I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily, expressed on activated T and B cells, Reed–Sternberg cells of classical Hodgkin lymphoma, and anaplastic large-cell lymphoma, where it regulates proliferation, apoptosis, and NF-κB signaling through TRAF1/2/5 adaptor proteins upon trimerization with its ligand CD30L (CD153), and serves as the validated target for the antibody–drug conjugate brentuximab vedotin that delivers the antimicrotubule agent monomethyl auristatin E into CD30-positive malignant cells.
流式分析
Flow cytometric analysis of C57BL/6 mouse splenocytes, treated 72 hours with Concanavalin A labeling CD30 at 1/400 dilution (0.5 μg) (Right panel) compared with a Amenian hamster IgG Isotype Control / (Left panel), followed by Anti-Armenian Hamster IgG (H+L) biotin and Sav-PE. Then cells were stained with CD3 - Brilliant Violet 421™ antibody separately.
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