Pacific Blue Armenian hamster Anti-Mouse CD11c Antibody (N418)

CD11c, also known as integrin alpha X (ITGAX), is a ~150 kDa type I transmembrane glycoprotein that pairs non-covalently with the 95 kDa beta2 integrin CD18 to form the αXβ2 heterodimer (complement receptor 4, CR4), which mediates cell adhesion, migration, and phagocytosis by binding diverse ligands such as iC3b, fibrinogen, ICAMs, and denatured proteins; it is predominantly expressed on myeloid dendritic cells, tissue macrophages, activated monocytes, and some B-cell subsets, serving as a classic marker for conventional dendritic cells in both mice and humans, and plays crucial roles in immune surveillance, antigen presentation, and inflammatory responses while also being implicated in autoimmune diseases and serving as a therapeutic target in cancer immunotherapy.