Biotin Mouse Anti-Human NKp44 (CD336) Antibody (S-3122)

NKp44 (CD336, NCR2) is a 44-kDa type I transmembrane glycoprotein of the immunoglobulin superfamily expressed exclusively on activated human NK cells (induced by IL-2 or IL-15) and on minor subsets of γδ T cells, ILC1/3 and plasmacytoid dendritic cells; it functions as an activating natural cytotoxicity receptor that, upon engagement with still-undefined cellular ligands, associates via a positively charged transmembrane residue with the ITAM-bearing adaptor DAP12 (KARAP) to trigger NK-cell cytotoxicity and secretion of IFN-γ and TNF-α against tumor or virus-infected targets, while a cytoplasmic ITIM sequence can also mediate inhibitory signals, giving the receptor dual functionality and making its selective expression a key activation marker whose reduction, as seen in HIV infection, correlates with impaired NK-cell activity.