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Mouse Anti-Human CD172a/b Antibody (S-3431)

Tyrosine-protein phosphatase non-receptor type substrate 1,SHP substrate 1,SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs (Bit),CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1 (Sirp-alpha-1),Signal-regulatory protein alpha-2 (Sirp-alpha-2),Signal-regulatory protein alpha-3 (Sirp-alpha-3),p84,SIRPA,BIT,MFR,MYD1,PTPNS1,SHPS1,SIRP Signal-regulatory protein beta-1,SIRP-beta-1,CD172 antigen-like family member B,CD172b,SIRPB1

价格 ￥600.00 （ 1-2周）
货号 S0B5808
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD172a/b

  • 分子别名

    Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1 (Sirp-alpha-1); Signal-regulatory protein alpha-2 (Sirp-alpha-2); Signal-regulatory protein alpha-3 (Sirp-alpha-3); p84; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b; SIRPB1

  • 细胞定位

    Cell membrane

  • Accession

    O00241, P78324

  • 克隆号

    S-3431

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG1,k

  • 反应种属 ?

    Hu

  • 阳性样本

    human peripheral blood Leukocytes

  • 纯化方式

    Protein G

  • 浓度

    2 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1:400 Hu
背景介绍

  • CD172a (SIRPα) and CD172b (SIRPβ1) are paired immunoglobulin-superfamily transmembrane glycoproteins that regulate myeloid-cell activation: CD172a binds CD47 to deliver inhibitory “don’t-eat-me” signals via SHP-1/2 phosphatases, controlling phagocytosis and dendritic-cell homeostasis, whereas CD172b lacks CD47 affinity and instead partners with the adaptor DAP12 to recruit SYK kinase and provide activating cues during innate immune responses.

  • 流式分析

    • Flow cytometric analysis of human peripheral blood Leukocytes labelling Human CD172a/b antibody at 1/400 (0.5 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody.

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