Alexa Fluor^® 647 Mouse Anti-Human CD62E Antibody (S-2909)

CD62E, also known as E-selectin or endothelial-leukocyte adhesion molecule-1 (ELAM-1), is a ~115 kDa calcium-dependent type-I transmembrane glycoprotein of the selectin family expressed exclusively on cytokine-activated vascular endothelium where it mediates the first tethering and rolling of circulating leukocytes by binding sialyl-Lewis X-decorated ligands such as PSGL-1 (SELPLG) on neutrophils, monocytes, and effector/memory T cells, thereby orchestrating extravasation during acute and chronic inflammation; the molecule comprises an N-terminal C-type lectin domain, an epidermal growth factor-like motif, six complement-binding (sushi/CCP) repeats, a single transmembrane segment, and a short cytoplasmic tail, is transcriptionally up-regulated within 2–4 h of stimulation by IL-1β, TNF-α, or LPS via an NF-κB–dependent pathway, and also participates in angiogenesis, tumor-cell metastasis, and vascular repair, making it both a biomarker and therapeutic target in cardiovascular disease, sepsis, and cancer.