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宿主来源
Mouse抗原名称
CD357分子别名
Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; AITR; GITR; TNFRSF18细胞定位
Cell membraneAccession
Q9Y5U5克隆号
S-3126抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD357, synonymous with GITR (glucocorticoid-induced TNFR-related protein) and TNFRSF18, is a type I transmembrane receptor of the tumor necrosis factor receptor superfamily that is constitutively expressed on CD25⁺CD4⁺ regulatory T cells and up-regulated on activated CD4⁺ and CD8⁺ T cells, NK cells, APCs and many tumors; upon binding its ligand TNFSF18 it recruits TRAF2 and TRAF5, triggering NF-κB and MAPK signaling that enhances effector T-cell proliferation, cytokine production and resistance to suppression by Tregs, positioning CD357 as a promising co-stimulatory target in cancer immunotherapy.
流式分析
Flow cytometric analysis of Human CD357 expression on PHA activated Human PBMC (human peripheral blood mononuclear cells). Human PBMC were untreated (Left panel) or cultured for 2 days in medium with 10μg/ml PHA (Right Panel) were then stained with SDT Biotin Mouse Anti-Human CD357 Antibody Antibody at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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