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宿主来源
Mouse抗原名称
Aiolos分子别名
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3细胞定位
Nucleus, CytoplasmAccession
Q9UKT9克隆号
S-3264抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
ICFCM
稀释度
应用 稀释度 推荐种属 ICFCM 1:200 Hu
Aiolos (encoded by IKZF3) is a zinc-finger transcription factor of the Ikaros family that is indispensable for lymphocyte biology. By recruiting chromatin-remodeling complexes to its target genes, it enforces quiescence in mature B cells, orchestrates immunoglobulin receptor editing, and cooperates with other Ikaros members to direct late-stage B-cell maturation. Its deletion or inactivating mutations unleash malignant transcriptional programs, making Aiolos a key tumor suppressor whose loss underpins B-cell acute lymphoblastic leukemia and multiple myeloma.
流式分析
Flow cytometric analysis of Foxp3 / Transcription Factor Staining Buffer Set fixed and permeabilized Human PBMC (human peripheral blood mononuclear cells) labelling Human Aiolos antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG1, κ (Left panel) isotype control. Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ antibody separately.
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