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宿主来源
Mouse抗原名称
CD80分子别名
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1 (B7); CD28LG; CD28LG1; LAB7细胞定位
Cell membraneAccession
P33681克隆号
S-3119抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Raji纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD80, also known as B7-1, is a co-stimulatory molecule expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation. Additionally, CD80 can bind to CTLA-4, an inhibitory receptor on T cells, which serves as a negative regulatory mechanism to control the extent of the immune response. This dual functionality highlights the importance of CD80 in both initiating and modulating immune reactions, making it a key target in immunotherapy research for conditions such as cancer and autoimmune diseases.
流式分析
Flow cytometric analysis of 293T (Human embryonic kidney epithelial cell, Left) / Raji (Human Burkitt's lymphoma B lymphocyte, Right) labelling CD80 antibody at 1/200 dilution (1 μg) / (Red) compared with a Mouse IgG1, κ Isotype control (Black) and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Negative control: 293T
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