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宿主来源
Mouse抗原名称
CD276分子别名
CD276 antigen; 4Ig-B7-H3; B7 homolog 3 (B7-H3); Costimulatory molecule; B7H3细胞定位
MembraneAccession
Q5ZPR3克隆号
S-2965抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human monocyte-derived mature dendritic cells纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD276, also known as B7-H3, is a type I transmembrane glycoprotein belonging to the B7 family of immune co-stimulatory molecules that is broadly overexpressed on the cell surface of many solid tumors while showing only limited distribution in normal tissues; it modulates both adaptive and innate immunity by interacting with putative receptors on T cells and NK cells to either inhibit or enhance anti-tumor responses, serves as a marker for cancer progression and poor prognosis, and is actively pursued as a therapeutic target through monoclonal antibodies, antibody–drug conjugates, CAR-T cells, and bispecific T-cell engagers.
流式分析
Flow cytometric analysis of Human CD276 expression on Human monocyte-derived mature dendritic cells. Human monocyte-derived mature dendritic cells were stained with FITC Mouse Anti-Human CD11c Antibody and either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (Left panel) or Alexa Fluor® 647 Mouse Anti-Human CD276 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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