Mouse Anti-Human CD1d Antibody (51.1)

CD1d is a transmembrane glycoprotein that belongs to the group 2 CD1 family of non-classical MHC class I-like antigen-presenting molecules, expressed on dendritic cells, thymocytes, hepatocytes and many other tissues; it forms a heterodimer with β2-microglobulin, folds into a deep, hydrophobic groove made up of A′ and F′ pockets that cradle lipid tails while exposing the glycosyl headgroups of self or microbial glycolipids, and delivers these antigens to the invariant T-cell receptor of CD1d-restricted natural killer T (iNKT) cells, thereby rapidly triggering large bursts of cytokines such as IFN-γ and IL-4 that shape innate and adaptive immune responses against infections, cancer, and autoimmune diseases .