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宿主来源
Mouse抗原名称
CD276分子别名
CD276 antigen; 4Ig-B7-H3; B7 homolog 3 (B7-H3); Costimulatory molecule; B7H3细胞定位
MembraneAccession
Q5ZPR3克隆号
S-2965抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood Leukocyte纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD276, also known as B7-H3, is a type I transmembrane glycoprotein belonging to the B7 family of immune co-stimulatory molecules that is broadly overexpressed on the cell surface of many solid tumors while showing only limited distribution in normal tissues; it modulates both adaptive and innate immunity by interacting with putative receptors on T cells and NK cells to either inhibit or enhance anti-tumor responses, serves as a marker for cancer progression and poor prognosis, and is actively pursued as a therapeutic target through monoclonal antibodies, antibody–drug conjugates, CAR-T cells, and bispecific T-cell engagers.
流式分析
Flow cytometric analysis of human peripheral blood Leukocyte labelling Human CD200R antibody at 1/200 (1 μg) dilution. Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD4 - Brilliant Violet 421™ antibody separately.
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