Mouse Anti-Human Granzyme A Antibody (S-3175)

Granzyme A (GZMA) is a 28 kDa serine protease stored in the cytotoxic granules of CD8⁺ T cells and NK cells; upon immunological synapse formation, it enters target cells together with perforin and cleaves after Lys or Arg residues to hydrolyze SET complex proteins (including the SET, APE1, and HMGB2 nucleases), thereby disrupting DNA repair and initiating a caspase-independent, oxidative DNA-damage cell death pathway that manifests as single-stranded DNA nicks, mitochondrial dysfunction, and plasma membrane perforation, while extracellularly it can process extracellular matrix components and cytokine precursors to modulate inflammation, vascular integrity, and antiviral immunity.