Mouse Anti-Human CD169 Antibody (S-2972)

CD169 (also called Siglec-1 or sialoadhesin) is a 175 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily expressed predominantly by subsets of tissue-resident macrophages and some dendritic cells; it contains 17 extracellular Ig-like domains whose distal V-set domain binds α2,3-linked sialic acids on host glycoproteins and glycolipids or on pathogens, enabling cell–cell and cell–matrix adhesion during inflammation, pathogen capture (e.g., PRRSV, SARS-CoV-2), antigen presentation, and modulation of innate and adaptive immunity, while its expression is up-regulated by interferons and correlates with disease activity in infections, inflammatory disorders, and cancer where CD169⁺ macrophages in tumor-draining lymph nodes are associated with better prognosis.