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宿主来源
Rat抗原名称
CD115分子别名
Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; FMS; CSF1R细胞定位
Cell membraneAccession
P07333克隆号
S-R722抗体类型
Rat mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood leukocyte纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD115, also known as Colony-Stimulating Factor 1 Receptor (CSF1R) or M-CSF receptor (M-CSFR), is a 972-amino-acid cell-surface glycoprotein encoded by the CSF1R gene (c-FMS proto-oncogene) that belongs to the type III receptor tyrosine kinase family; it serves as a receptor for the cytokines CSF-1 and IL-34, and is highly expressed on monocyte-lineage cells and osteoclasts, mediating their survival, proliferation, differentiation, and motility through ligand-induced oligomerization and transphosphorylation, with mutations linked to myeloid malignancies and increased expression observed in Alzheimer’s disease microglia and breast carcinogenesis .
流式分析
Flow cytometric analysis of human peripheral blood leukocyte labelling human CD115 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG1, κ Isotype Control / (left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody.
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